camila September 27, 2021

SEOUL (BLOOMBERG) – In the world of finance, leveraged buyouts are sometimes seen as controversial – the domain of fictional villain Gordon Gekko from the movie Wall Street – where firms borrow large sums of money to buy their targets. But Mr Kyungsun Chung, a grandson of the Hyundai Motor empire founder Chung Ju Yung, is […]

camila September 27, 2021

HONG KONG (BLOOMBERG) – China Evergrande Group’s electric car unit will not proceed with its proposed issue of yuan-denominated shares on the Science and Technology Innovation Board of the Shanghai Stock Exchange, according to a filing to the Hong Kong stock exchange. The Hong Kong-listed unit of troubled China Evergrande Group and Haitong Securities have […]

camila September 27, 2021

SINGAPORE – Manpower and building material costs in the construction sector have spiked since the Covid-19 pandemic began, delaying projects and hitting the cash flow for companies in the supply chain. Here are the main costs companies are grappling with: 1. Salaries Before the pandemic, a basic-skilled worker earned about $800 a month, The Straits […]

camila September 27, 2021

SINGAPORE – Contractors in Singapore could face yet another hurdle next month, after the temporary relief period protecting them from claims and other legal proceedings expires. Lawyers told The Straits Times that there are signs of lawsuits brewing, with contractors preparing for contract disputes when the relief period under the Covid-19 (Temporary Measures) Act ends […]

camila September 27, 2021

SINGAPORE – If you did not know what Evergrande was about a month or two ago, you would have had more than your fill over the past week. The debt saga involving the China-based property giant has hogged the headlines all week and rattled market sentiment, not just in China and Hong Kong, but in […]

camila September 27, 2021

SINGAPORE – The recent tie-ups between Singapore’s PayNow service and similar systems in Thailand and India is set to bring more competition to the cross-border payments scene. That prospect does not seem to daunt existing players in the sector, who told The Straits Times that they welcome the developments and are beefing up their operations […]

megan September 26, 2021

SHANGHAI, Sep 26, 2021 – (ACN Newswire via SEAPRWire.com) – Hua Medicine (“Hua Medicine”; SEHK: 2552) today announced that at the 6th China BioMed Innovation and Investment Conference held September 25-27 in Suzhou, China (the “CBIIC”), Professor Jianhua MA, Director of the Department of Endocrinology, Nanjing First Hospital, Standing Member of the Chinese Diabetes Society, […]

estel September 26, 2021

SHANGHAI, Sep 26, 2021 – (亚太商讯 via SEAPRWire.com) – 华领医药(「公司」,香港联交所股份代号:2552.HK)今天宣布,在苏州举办的第六届中国医药创新与投资大会(The China BioMed Innovation and Investment Conference,以下简称CBIIC)上,中华医学会糖尿病学分会常委、南京市第一医院内分泌科主任马建华教授作为主要研究者之一,公布了一项名为DREAM的临床研究结果,研究显示华领医药全球首创新药葡萄糖激酶激活剂多格列艾汀(dorzagliatin) 有望在糖尿病缓解方面取得进展。 DREAM研究是一项由参与SEED研究(播种研究,又称HMM0301)的部分研究者发起的,非药物干预的观察性临床研究。 SEED研究是一项多格列艾汀单药治疗III期注册临床研究,在新诊断未用降糖药治疗的2型糖尿病患者中展开,观察多格列艾汀单药治疗的长期疗效和安全性。 DREAM研究主要考察参与SEED研究的患者血糖达标后,在不服用任何降糖药物、仅采用生活方式干预的情况下,其后至少52周的糖尿病控制情况,观察其血糖能否维持在正常或接近正常水平,以探索多格列艾汀停药后对糖尿病缓解的作用。 DREAM研究在中国5家研究中心、共69名患者中开展。研究者综合评价受试者情况,设定其HbA1c个体控制目标,研究结果显示,研究期内,受试者52周糖尿病缓解率为65.2%(置信水平95%,置信区间53.4%~77.0%)[1]。 马建华教授表示:「多格列艾汀作为全新的葡萄糖激酶激活剂类药物,可以有效改善胰岛素早相分泌,改善β细胞功能和胰岛素抵抗。在此前的SEED研究中,多格列艾汀单药治疗也表现出长期稳定疗效和良好的安全性。DREAM研究再次展现出积极的研究结果,患者经过多格列艾汀治疗血糖达标后,在停药状态下,血糖情况和β细胞功能仍能够维持,这一成果有助于我们更加深入地了解糖尿病缓解的机制,并在临床治疗中为患者寻求更为有力的治疗手段。DREAM研究探索了口服用药在糖尿病缓解中的可能性,对于拓展2型糖尿病的治疗方案具有重要意义。」 本次CBIIC上,除了DREAM研究成果,华领医药CEO、创始人、首席科学官陈力博士还在上市公司专场中对2型糖尿病的药物治疗格局进行了分析,并分享了华领医药的发展经验和未来发展展望。 陈力博士表示:「中国是全球糖尿病患者最多的国家,2型糖尿病患者数量已经超过1.2亿。根据2020年中国研究者BMJ上发表的流行病学研究,2015-2017年中国大陆糖尿病和糖尿病前期发病率分别为12.8%和35.2%,糖尿病防控已经成为关系国计民生的重要战略任务。近日美国糖尿病协会发布的关于糖尿病缓解的共识报告,再次引发了临床医生和新药开发者对于避免糖尿病成为终身疾病的思考。DREAM研究的积极结果增强了我们根治2型糖尿病的信心。华领医药将继续以多格列艾汀为基础,探索单药治疗和联合用药的广阔前景,同时进一步开展分型研究,综合运用大数据和人工智能等手段对2型糖尿病进行精准治疗。华领医药还将立足于中国老百姓的未被满足的临床需求,积极打造葡萄糖激酶药物开发平台,力争在神经退变性疾病、非酒精性脂肪肝等疾病领域取得新的突破。」 注释:[1] 使用生存分析法计算 关于多格列艾汀多格列艾汀(dorzagliatin)是一款在研的全球首创双作用的葡萄糖激酶激活剂,旨在通过恢复2型糖尿病患者的血糖稳态来控制糖尿病渐进性退变性疾病发展。通过修复葡萄糖激酶的葡萄糖传感器功能的缺陷,多格列艾汀具有恢复2型糖尿病患者受损的胰岛素和GLP-1分泌的潜力,有望作为该疾病源头治疗的基石药物。目前,公司已经完成多格列艾汀单药治疗和与二甲双胍联合用药的两项III期注册临床研究,以及与DPP-4抑制剂西格列汀和SGLT-2抑制剂恩格列净的联合用药机制协同性研究。公司已获得由上海市药品监督管理局颁发的多格列艾汀《药品生产许可证》,并已获得国家药品监督管理局的新药上市申请受理,以早日实现多格列艾汀的「全球首创,中国首发」,造福广大糖尿病患者。 关于华领华领医药是一家立足中国,针对全球糖尿病患者尚未满足的临床需求,研发全球原创新药的生物技术公司。华领医药汇聚全球高端人才和科技资源,以国际领先生物医药投资团队为依托,成功将一款全球首创2型糖尿病口服新药推进到NDA阶段。目前,公司已经在中国完成两项多格列艾汀III期注册临床研究。公司已启动药品全生命周期管理相关临床试验,并拓展糖尿病个性化治疗和管理的先进理念。通过与中国和全世界范围内的糖尿病领域专家和机构的密切合作,华领医药将为全世界糖尿病患者带来全新的治疗方案。 关于DREAM研究DREAM研究是一项由参与SEED研究(播种研究,又称HMM0301)的部分研究者发起的,非药物干预的观察性临床研究,以评估多格列艾汀对新诊断未用降糖药治疗的2型糖尿病患者的疗效。尽管公司在评估相关数据和研究结果方面为研究者提供了帮助,但公司没有设计或管理DREAM研究,也不拥有或管理研究的基础数据。 详情垂询华领医药 网址:www.huamedicine.com投资者 电邮:ir@huamedicine.com媒体 电邮:pr@huamedicine.com 此新闻稿由博达浩华国际财经传讯公司代表华领医药发布。如有垂询,请联络:博达浩华国际财经传讯公司李耀荣先生 +852 3150 6707 bunny.lee@pordahavas.com陈欣榆小姐 +86 75523807432 louisa.chen@pordahavas.com赵芷晴小姐 +852 3150 6726 karen.chiu@pordahavas.com谭颖茵小姐 +86 15915975512 winnie.tan@pordahavas.com Copyright 2021 亚太商讯. All rights reserved. (via […]

camila September 26, 2021

MUNICH (NYTIMES) – Before the pandemic, German car shows looked like this: Automakers competed to occupy the most floor space. Gleaming new models were unveiled to the accompaniment of cheesy light shows. Throngs of mostly male visitors ogled displays of the latest in horsepower and luxury from Wolfsburg, Munich and Stuttgart. But the throngs had […]

camila September 26, 2021

(NYTIMES) – Maybe you lost your job. Maybe your hours were cut. Or maybe you had to take over caregiving responsibilities. If your income fell precipitously in the past 18 months – even if things have become better – it is an uncertain time. High inflation in some sectors does not help, and neither do […]

camila September 26, 2021

(NYTIMES) – The Federal Reserve’s low interest rate policies and other steps meant to boost the economy are driving the value of stocks and other assets to the moon and thus are a major cause of high wealth inequality. New evidence suggests high inequality is the cause, not the result, of the low interest rates […]

camila September 26, 2021

(NYTIMES) – Cryptocurrencies have emerged as one of the most captivating, yet head-scratching, investments in the world. They soar in value. They crash. They’ll change the world, their fans claim, by displacing traditional currencies like the dollar, rupee or ruble. And in the process of simply existing, cryptocurrencies like Bitcoin, one of the most popular, […]

camila September 26, 2021

No one doubts the past 18 months have been rough, not just for ordinary folk coping with a pandemic but also those in the medical system who somehow need to keep their own heads and health through all the trauma. IHH Healthcare – which owns hospitals branded as Parkway, Pantai and Fortis – has been […]

camila September 26, 2021

SINGAPORE – Many of us have more than one credit card, but having piles of plastic does not mean you have more back-up credit lines if you have busted on one. Here are four things about debt you should know. Please subscribe or log in to continue reading the full article. Get unlimited access to […]

camila September 26, 2021

SINGAPORE – Many love stories start with the usual courtship rituals, but this boy-meets-girl tale ended especially badly with an unusual twist. That the twist involved money should not come as a total surprise, of course, given the Singapore Dream often involves a property and that in turn always involves big bucks. Please subscribe or […]

camila September 26, 2021

SINGAPORE – Finance industry executive Lawrence Chan could probably write a book about the long-term value of bricks and mortar as an investment, but two phrases sum it up – capital gains and recurring rental income. As Mr Chan, 52, notes: “Land is scarce in Singapore and historical data has proven that real estate appreciates […]

camila September 26, 2021

More individuals and institutions today are looking to generate positive returns for themselves and the world through sustainable investing. This approach of incorporating environmental, social and governance (ESG) factors into investment decisions, once seen as a niche strategy that trades returns for virtuosity, is now mainstream. “While sustainability is not new, the megatrend that has […]